Thursday, 3 November 2005: 12:30 PM-3:00 PM
Regency Ballroom E (Hyatt Regency Cincinnati)

Engineering Fundamentals in Life Science (15d)

#495 - Culture Strategies to Enhance Engineered Tissue Phenotype (15D21)
The field of tissue engineering seeks to create clinically effective materials for the repair of damaged tissues and organs and the treatment of medical conditions brought on by trauma, disease or congenital defects. Tissue engineering strategies involve the incorporation of novel biomaterials with biologics and/or pharmaceutics, that upon implantation in the patient will stimulate angiogenesis, tissue integration, and/or tissue remodeling. Critical to the development of effective tissues are strategies that enhance phenotypic markers of the target tissue, and may include approaches that regulate cell adhesion, intercellular communication, activation of receptor-mediated signaling pathways, or mechanotransduction. This session seeks abstracts that describe novel in vitro strategies to enhance phenotypic markers of engineered tissues, including (but not limited to) liver, pancreas, retina, muscle, skin, tendon, cartilage, bone, vascular, and nerve.
CoChair:Vassilios I. Sikavitsas
Chair:Aaron S. Goldstein
12:30 PMInvestigation of Chemical Effects on Neural Progenitor Cell Adhesion and Differentiation Using Micropatterned Substrates
Erin Boote Jones, Jennifer Recknor, Donald S. Sakaguchi, Surya K. Mallapragada
12:50 PMApplication of Micropatterning Techniques to Co-Culture Systems for Hepatic Tissue Engineering
Cheul H. Cho, Jae-Sung Park, Francois Berthiaume, Arno W. Tilles, Mehmet Toner, Martin L. Yarmush
1:10 PMPreventing Hepatocyte Steatosis by Co-Culture with Adipocytes during Plasma Exposure
Deepak Nagrath, Vanessa Lopez, Francois Berthiaume, Martin Yarmush
1:30 PMMorphological and Functional Responses of Hepatocytes Cultured on Glycosaminoglycan-Chitosan Membranes
Therese Bou-Akl, Basak Saygili, Howard W.T. Matthew
1:50 PMIntermission
2:00 PMUsing Bone-like Ecm Produced in Vitro to Influence Osteoblastic Differentiation of Marrow Stromal Cells
Upma Sharma, Quynh Pham, Neha Datta, Antonios Mikos
2:20 PMSeeding of Scaffolds for Tissue Engineering in a Flow Perfusion Bioreactor Improves Efficiency and Cell Distribution
Jose F. Alvarez-Barreto, Shawna Linehan, Jessica Yankovich, Robert L. Shambaugh, Vassilios I. Sikavitsas
2:40 PMBioreactor Optimization of Scaffold Seeding for Cartilage Tissue Engineering
Bahar Bilgen, Ericka M. Bueno, Gilda A. Barabino
Sponsor:Food, Pharmaceutical & Bioengineering Division

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