| Monday, 31 October 2005: 12:30 PM-3:00 PM | |||
| Regency Ballroom G (Hyatt Regency Cincinnati) | |||
Pharmaceuticals (15b) | |||
| #52 - Advances in Protein Structure, Function, and Stability: Part II (15B06) | |||
| This session seeks submissions in the areas of experimental, theoretical, and computational approaches to rational prediction, design, and/or optimization of protein structure, stability, and function in laboratory and processing settings relevant to biopharmaceutical products in general. Studies may include structural analysis and engineering of proteins, creation or optimization of function, thermodynamics and dynamics of protein conformational stability, issues in folding or misfolding, degradation via physical and chemical routes, or related concerns in intracellular expression and refolding, purification, and final product formulation. Preference will be given to papers dealing with strategies that are relevant to commercial and biological systems and also provide insights into the molecular pathways or mechanisms controlling behavior. | |||
| CoChair: | Jeffrey J. Gray | ||
| Chair: | Christopher J. Roberts | ||
| 12:30 PM | 52a | The Effect of Various Small Heat Shock Proteins on Prevention of Beta Amyloid Aggregation and Toxicity Sungmun Lee, Theresa A. Good | |
| 12:50 PM | 52b | Identification of Inhibitory Binding Faces of ß-Amyloid Fibril Formation Melissa A. Moss | |
| 1:10 PM | 52c | Cell Membrane-Mediated Amyloid-Beta Fibrillogenesis Eva Y. Chi, Canay Ege, Ka Yee C. Lee | |
| 1:30 PM | 52d | An Improved Model of Non-Native Protein Aggregation Kinetics Jennifer M. Andrews, Christopher J. Roberts | |
| 1:50 PM | Intermission | ||
| 2:00 PM | 52e | Simulation of Polyglutamine Aggregation with an Intermediate Resolution Protein Model Alexander J. Marchut, Carol K. Hall | |
| 2:20 PM | 52f | Molecular Dynamics Simulations of Surfactant-Assisted Protein Folding in Vitro Diannan Lu, Zheng Liu, Jianzhong Wu | |
| 2:40 PM | 52g | Reversible Changes in Protein Secondary Structure with Light Using Photoresponsive Surfactants Shao-Chun Wang, C. Ted Lee Jr. | |
| Sponsor: | Food, Pharmaceutical & Bioengineering Division | ||
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