| Monday, 31 October 2005: 8:00 AM-10:30 AM | |||
| Regency Ballroom G (Hyatt Regency Cincinnati) | |||
Pharmaceuticals (15b) | |||
| #13 - Advances in Protein Structure, Function, and Stability I (15B15) | |||
| This session seeks submissions in the areas of experimental, theoretical, and computational approaches to rational prediction, design, and/or optimization of protein structure, stability, and function in laboratory and processing settings relevant to biopharmaceutical products in general. Studies may include structural analysis and engineering of proteins, creation or optimization of function, thermodynamics and dynamics of protein conformational stability, issues in folding or misfolding, degradation via physical and chemical routes, or related concerns in intracellular expression and refolding, purification, and final product formulation. Preference will be given to papers dealing with strategies that are relevant to commercial and biological systems and also provide insights into the molecular pathways or mechanisms controlling behavior. | |||
| CoChair: | Christopher J. Roberts | ||
| Chair: | Jeffrey J. Gray | ||
| 8:00 AM | 13a | Protein Switches Created by Non-Homologous Recombination Gurkan Guntas, Jing Liang, Jin Ryoun Kim, Thomas J. Mansell, Jason Boock, Marc Ostermeier | |
| 8:20 AM | 13b | An Engineered Chimeric Enzyme for Use in Drug Sensing, Discovery and Development David W. Wood, Georgios Skretas | |
| 8:40 AM | 13c | De Novo Engineering of a Bacterial Disulfide Isomerase Laura Segatori, Silvia Arredondo, George Georgiou | |
| 9:00 AM | 13d | Directed Evolution of Homing Endonuclease with Altered DNA Sequence Specificity Zhilei Chen, Huimin Zhao | |
| 9:20 AM | Intermission | ||
| 9:30 AM | 13e | Engineering of High Affinity Binding Peptides Using N-Terminal Bacterial Display Jeffrey J. Rice, Aaron Schohn, Patrick S. Daugherty | |
| 9:50 AM | 13f | Computational Prediction of the Mab 806-Egfr Complex Structure by Combining Protein Docking with Computational and Experimental Mutagenesis Arvind Sivasubramanian, Ginger Chao, K. Dane Wittrup, Jeffrey J. Gray | |
| 10:10 AM | 13g | Measurements of Protein Folding and Unfolding Kinetic Pathways Using a Microfluidic Approach Jinkee Lee, Joshua Ziperstein, Anubhav Tripathi | |
| Sponsor: | Food, Pharmaceutical & Bioengineering Division | ||
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