Thursday, 3 November 2005: 12:30 PM-3:00 PM
Wolverine AB (Hyatt Regency Cincinnati)

Topical 8 - Bioseparations (T8)

#523 - Protein Chromatography and Chiral Resolution of Biomolecules (T8006)
The focus of this session is to identify the latest theoretical and experimental advances in the use of chromatography for protein purification. Applications can range from large scale manufacturing to microscale proteomic applications. Topics to be covered will include, but are not limited to: Affinity chromatography, Ion exchange chromatography, Hydrophobic chromatography, Simulated moving bed chromatography, membrane chromatography, multidimensional chromatography and chip based systems.
CoChair:Jennifer Kuehne
Chair:Steven Cramer
12:30 PMCartridge Filter Separation System: an Alternative to Column Chromatography in Downstream Purification of Protein Therapeutics
Masayuki Nakamura, Kelly J. Gibbens, Robert T. Fitzsimons, Andrew W. Rabins, Kannan Seshadri, Steve M. Larsen, Douglas A. Hanggi, Catherine A. Bothof, Larry J. Carson, Gustov H. Castro, James I. Hembre, Patrick L. Coleman, Jarald K. Rasmussen, Steven M. Heilmann
12:50 PMFunctionalized Nanoporous Molecular Sieves for Chromatographic Separations of Proteins
Amit Katiyar, Panagiotis (Peter) Smirniotis, Neville G. Pinto
1:10 PMProtein C Purification Using Pc Specific Mini-Mab from the Inexpensive Source, Cohn Blood Plasma Fraction VI-1
Samin Rezania, Doh Gyeuhn Ahn, Kyung A. Kang
1:30 PMInvestigation of Protein Adsorption and Similarity Measurement for Protein Binding Behavior in Hydrophobic Interaction Chromatography (Hic) System
Jie Chen, Qiong Luo, Matthew C. Sundling, Abigail H. Laurent, Jace L. Fogle, Yunzhi Xiao, Curt M. Breneman, Erik J. Fernandez, Todd M. Przybycien, Steven M. Cramer
1:50 PMIntermission
2:00 PMResolution of Racemic Mixtures Coupling Crystallization and Simulated Moving Bed: Fundamental Studies for S-Ketamine Production
Georgia O. F. Barros, Everson A. Miranda
2:20 PMMutants of Phenylalanine Dehydrogenase: New Bio-Catalysts in the Asymmetric Synthesis and Racemic Resolution of Non-Natural Aminocids
Paul C. Engel, Francesca Paradisi, Eamonn Moynihan, Anita R. Maguire
2:40 PMMolecular Mechanisms of Selective Sorption of Chiral Enantiometers on Amylose-Based Sorbents
Rahul B. Kasat, Kendall Thomson, Hugh W. Hillhouse, Linda Wang, Elias I. Franses
Sponsor:Topical 8 - Bioseparations

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