Thursday, 3 November 2005: 8:00 AM-10:30 AM
Regency Ballroom E (Hyatt Regency Cincinnati)

Engineering Fundamentals in Life Science (15d)

#457 - Engineering Improvements in Cancer Diagnosis and Therapy: Novel Therapeutic Approaches (15D17)
Tremendous advances in biology, including but not limited to high-profile areas such as genomics and stem cells, have provided new hope for improvements in the diagnosis and treatment of cancer. Engineers have much to offer in this endeavor, in areas such as mathematical modeling (at levels ranging from whole body pharmacokinetic down to cellular and molecular dynamics), transport in tumors, development of novel drug delivery strategies and data mining. This session will highlight chemical and bio-engineering methodologies for bringing these hopes closer to practice. Studies involving modeling, experiments or both are welcome. This session will particularly highlight novel therapeutic approaches, such as: personalized medicine based on genetics and gene expression profiles, angiogenesis and anti-angiogenic therapies, targeted drug delivery approaches, gene and oligonucleotide therapies.
CoChair:Neil S Forbes
Chair:Charles M. Roth
8:00 AMIsolation of Tumor Targeting Peptides Using Fluorescent Bacterial Display Libraries
Karen Y. Dane, Jeffrey J. Rice, Patrick S. Daugherty
8:20 AMTargeting L-Methioninase to Human Cancer Cells
Naveen R. Palwai, Xiao-Ping Zang, J. Thomas Pento, Roger G. Harrison
8:40 AMEngineering Antibodies against the Epidermal Growth Factor Receptor to Block Dimerization
Ginger Chao, Mark Olsen, Alejandro Wolf-Yadlin, K. Dane Wittrup
9:00 AMTargeting Cd47 as an Apoptotic Trigger of Human Lung Carcinoma Tumors
Fariyal Ahmed, Shyamsundar Subramanian, M. Tewari, Dennis E. Discher
9:20 AMIntermission
9:30 AMDesign of Effective Cancer Treatment Strategies Using Systemically Delivered Sirna: Insights from in Vivo Studies and a Mathematical Model of RNA Interference
Derek W. Bartlett, Mark E. Davis
9:50 AMNovel Alternating Copolymer Structures for Targeted in Vivo Imaging and Therapy in Cancer
Michelle T. Hardiman, Jin Zhou, Robert J. Fisher, Clark K. Colton, Rajesh Kumar, Rahul Tyagi, Virinder S. Parmar, Arthur C. Watterson
10:10 AMThe Scale-up of T Cell Depletion for Mismatched Bone Marrow Transplants
Ying Xiong, Xiaodong Tong, Sherif Farag, Jeffrey Chalmers
Sponsor:Food, Pharmaceutical & Bioengineering Division

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