Monday, 31 October 2005: 8:00 AM-10:30 AM
Regency Ballroom E (Hyatt Regency Cincinnati)

Engineering Fundamentals in Life Science (15d)

#25 - Gene Delivery (15D09)
The field of gene therapy and vaccine design has made significant strides in the past several years, but significant challenges remain, particularly in the design and optimization of gene delivery vehicles. This session will focus on issues related to vector design, both viral and synthetic. These issues will include investigations of the mechanism of gene delivery by various vectors, including analysis of interactions between vectors, tissues, and cells in the steps involved in the gene delivery pathway. In addition, emphasis will be placed on the design and enhancement of vectors to improve their capabilities, including efficiency and targeting, and we encourage analysis of the structure-function relationship of delivery vehicles. Finally, this session will also discuss methods to improve the production of both viral and nonviral vehicles.
CoChair:David V. Schaffer
Chair:Stelios T. Andreadis
8:00 AM25aEgf Receptor Signaling Affects Retroviral Gene Transfer to Primary Epidermal Cells
Raghvendra Singh, Stelios T. Andreadis
8:20 AM25bEngineering Enhanced Retroviral Vectors for Gene Therapy through the Generation and Selection of 6xhis Peptide Insertion Libraries into Vsv-G
Julie H. Yu, David V. Schaffer
8:40 AM25cBaculovirus Transduction of Human Mesenchymal Progenitor Cells Is Dependent on Differentiation Lineages
Yi-Chen Ho, Kuei-Chun Wang, Shiaw-Min Hwang, Yu-Chen Hu
9:00 AM Intermission
9:10 AM25dEnhanced Stability of Retrovirus by Directed Evolution
Halong Vu, Daniel W. Pack
9:30 AM25ePopulation Dynamics of Defective Interfering Virus-like Particles
Kristen Stauffer, John Yin
9:50 AM25fEnhancement of Retroviral Transduction Using Electrical Fields
Yu-Hsiang Lee, Ching-An Peng
Sponsor:Food, Pharmaceutical & Bioengineering Division

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