Thursday, 3 November 2005: 8:00 AM-10:30 AM
Buckeye A (Hyatt Regency Cincinnati)

Pharmaceuticals (15b)

#446 - Application of ChE Fundamentals to Active Pharmaceutical Ingredient (API) Process Development (15B05)
This session focuses on the application of chemical engineering principles to extract kinetic, thermodynamic and transport parameters from data-rich experiments at the lab and pilot plant scale. Of particular interest are talks related to the development of robust, cost-effective and scaleable processes for API and intermediate production.
CoChair:Shekhar K. Viswanath
Chair:Shailendra V. Bordawekar
8:00 AMSolvent and Catalyst Recovery in the Pharmaceutical Manufacturing Industry
Jason Davis, Joseph T. Sullivan, Nick Anousis
8:20 AMBatch Grinding Kinetics and Particle Shape of Active Pharmaceutical Ingredients by Fluidized-Bed Jet-Milling
Tadashi Fukunaka, Boris Golman, Kunio Shinohara
8:40 AMDrying of a Monohydrate Api under Thermodynamically Safe Conditions
G. Scott Jones, Raymond Scaringe, Shawn Yin
9:00 AMEstimating Solubility of Organic Salts with Enrtl-Sac Model
Chau-Chyun Chen, Yuhua Song
9:20 AMIntermission
9:30 AMTrouble-Shooting of High Residual Solvent during Drying of Biological Derived Api
Yubo Yang, Stephen Tyler, Kenneth Wilson
9:50 AMStudying Hydraulic Deterioration of Large Scale Chromatography Columns
Harish Santhanam, Yi Xie
10:10 AMDevelopment of Efficient and Robust Nitro Reduction Process: Catalyst Selection and Thermo-Kinetic Understanding
Jale Muslehiddinoglu, Srinivas Tummala, Nicolas Cuniere, William Merkl, Richard Schild, Lucius Rossano
Sponsor:Food, Pharmaceutical & Bioengineering Division

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