Tuesday, 1 November 2005: 12:30 PM-3:00 PM
Regency Ballroom E (Hyatt Regency Cincinnati)

Pharmaceuticals (15b)

#194 - Advances in Drug Delivery: Biological Barrier Transport (15B03)
This session invites papers that focus on the design and development of novel methods for controlled drug delivery across the biological barriers, such as blood-brain, blood-retinal, intestinal and nasal barriers. These methods can incorporate, for example, nanocarriers, electrical field, magnetic field or ultrasound. Topics of interest include, but are not limited to: in vitro and in vivo studies of the effects of the delivery protocol on the integrity of the biological barriers, cellular uptake of nanocarrier/drug complexes, enhanced permeability mechanisms, and bioefficacy of penetrated drugs.
CoChair:Cory J. Berkland
Chair:Tao L. Lowe
12:30 PMDesign Principles of Chemical Permeation Enhancers for Transdermal Drug Delivery
Pankaj S. Karande, Amit K. Jain, Samir Mitragotri
12:50 PMFundamental Investigation of Transdermal Transport Models for Hydrophobic and Hydrophilic Drugs
Joseph Kushner IV, Daniel Blankschtein, Robert Langer
1:10 PMTransport of Amitriptyline across Capillary Walls in Isolated Rat Hearts
Marissa Fallon, Jason A Flint, Timothy E Morey, Donn M Dennis, Anuj Chauhan
1:30 PMA Facile and Reproducible in Vitro Blood-Brain Barrier Model
Eric Shusta, Anthony R. Calabria, Christian Weidenfeller
1:50 PMBreak
2:00 PMin Vivo Characterization of Microfluidic Probes for Convection Enhanced Drug Delivery
Keith B. Neeves, William L. Olbricht, W. Mark Saltzman
2:20 PMNovel Nanoparticles for Controlled Drug Delivery across the Blood-Brain Barrier
Sailendra N. Nichenametla, Annie Mitsak, James Bauer, Young Shin Kim, Tao L. Lowe
2:40 PMExperimental and Theoretical Modeling of Intracellular Drug Delivery Following Acoustic Cavitation
Vladimir G. Zarnitsyn, Robyn K. Schlicher, Christina Allen, Mark R. Prausnitz
Sponsor:Food, Pharmaceutical & Bioengineering Division
Cosponsors:Topical 8 - Bioseparations

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