Preliminary Program subject to change
02B05 Polymorphism In Pharmaceutical Development
OverviewPresentations are solicited for polymorphism of substances related to the development of active pharmaceutical ingredients. This includes methods for discovering and producing the most stable form. The impact of form selection on a reproducible manufacturing process for a stable drug substance or formulated drug product is also of interest. Papers which examine strategies/methodologies for the control of polymorphism during crystallization, drying, storage and formulation are most welcomed. This may include but is not limited to the affect of solvent composition, particle size, shear environment, seeding and reactor configuration. The novel use of process analytical technologies for monitoring and control of crystallizations is also an important component to be covered in this session.
Primary SponsorCrystallization and Evaporation (02b)
Co-Sponsor(s)Pharmaceuticals (15b)

Chair

Thomas LaPorte
Pharmaceutical Research Institute
Bristol-Myers Squibb
One Squibb Drive
New Brunswick, NJ 08903
Phone Number: 732-227-7042
Fax Number: 732-227-3930
Email: thomas.laporte@bms.com

CoChair

Priscilla J. Hill
Assistant Professor
Mississippi State University
Box 9595
Swalm School of Chemical Engineering
Mississippi State, MS 39762
Phone Number: 662-325-8249
Fax Number: 662-325-2482
Email: phill@che.msstate.edu
Concomitant Nucleation of Polymorphs
Aniruddh Singh, In Sung Lee and Allan S. Myerson, Department of Chemical and Biological Engineering, Illinois Institute of Technology, 10 West 33rd St., Suite 223, Chicago, IL 60616
Modeling and Prediction of the Crystal Structure of Pharmaceutical Co-Crystals
Panagiotis G. Karamertzanis1, Andrei V. Kazantsev2, N. Issa3, G. W. a. Welch3, Claire S. Adjiman4, Constantinos C. Pantelides5 and Sally L. Price3, (1)Imperial College London, Centre for Process Systems Engineering, London, SW7 2AZ, United Kingdom, (2)Department of Chemical Engineering, Imperial College London, Centre for Process Systems Engineering, London, SW7 2AZ, United Kingdom, (3)Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, United Kingdom, (4)Department of Chemical Engineering, Imperial College London, Centre for Process Systems Engineering, South Kensington Campus, London, SW7 2AZ, United Kingdom, (5)Imperial College London / Process Systems Enterprise Ltd, Centre for Process Systems Engineering, London, SW7 2AZ, UK
Pseudopolymorphic Transitions of Sodium Naproxen In Mixed-Solvent Systems
Krystle J. Chavez and Ronald W. Rousseau, School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332-0100
Achieving Desired Polymorphs In API Process Development
Chenchi Wang, Qi Gao, Beth Sarsfiled, Yuping Qiu, Victor Rosso and Chiajen Lai, Research and Development, Bristol-Myers Squibb Company, One Squibb Drive, New Brunswick, NJ 08903
In-Situ Controlling and Monitoring of Polymorphic Crystallization and Transformation
Xia Yang1, Xiujuan Wang2 and Chi Bun Ching2, (1)School of Chemical and Biomedical Engineering, Nanyang Technology University, Singapore 637459, 62 Nanyang Drive, Singapore, Singapore, (2)School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore, 637459, Singapore
Polymorph Transformation by High Shear—a Case Study
Chiajen Lai, Qi Gao, Ming-Hsing Huang, David Leahy, Jun Li, Alicia Ng and Justin Sausker, Bristol-Myers Squibb Company, One Squibb Drive, New Brunswick, NJ 08903
Crystallization and Polymorphism of Chiral Compounds
Qi Gao and Alicia Ng, Analytical R&D, Bristol-Myers Squibb, 1 Squibb Drive, New Brunswick, NJ 08901

Separations Division