Preliminary Program subject to change
15B15 Science and Engineering in Crystallization
OverviewRobust crystallization of API with desired properties often requires a seamless interface between crystallization science and engineering principles. Crystallization science governs the chemical interactions that drive both nucleation and growth. Engineering principles provide the tools for scale-up and finesse the process. In this section, we invite authors to submit papers that apply both science and engineering to solve challenging scale-up problems, such as polymorph and enantiomer crystallization, particle size manipulation, and habit modification, to name a few.
Primary SponsorPharmaceuticals (15b)
Co-Sponsor(s)Crystallization and Evaporation (02b)

Chair

Hector Guzman
TransForm Pharmaceuticals Inc.
29 Hartwell Avenue
Lexington, MA 02421
Phone Number: 781-674-7882
Fax Number: 781-863-8914
Email: hguzman@tpius.jnj.com

CoChair

Monica H. Lamm
Department of Chemical and Biological Engineering
Iowa State University/DOE Ames Laboratory
A510 Zaffarano Hall
Ames, IA 50011
Phone Number: 515-294-6533
Fax Number: 515-294-6027
Email: mhlamm@iastate.edu
Linear Models for Prediction of Ibuprofen Crystal Morphology Based on Hydrogen Bonding Propensities
Charles Acquah, Chemical Engineering, University of Connecticut, Storrs, CT 06269, Arunprakash T. Karunanithi, U.S. Environmental Protection Agency, 26 W. Martin Luther King Drive, Cincinnati, OH 45268, Matthew Cagnetta, Department of Chemical, Materials and Biomolecular Engineering, University of Connecticut, 191 Auditorium Rd, U-3222, Storrs, CT 06269, Luke E. K. Achenie, Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Randolph Hall 133, Blacksburg, VA 24061 and Steven Suib, Department of Chemistry, Chemical Engineering and Institute of Material Science, University of Connecticut, Storrs, CT 06269
Mechanism of the Formation of Enantiotropic Polymorphs in Solution Crystallization
Wenju Wu, Pharmceutical Sciences, JJPRD, 1000 Route 202, OMP Building B241-D, Raritan, NJ 08869
Polymorph Selection In Solution Crystallization: Is Kinetics the Primary Determinant?
Sendhil K. Poornachary, Guangjun Han, Pui Shan Chow and Reginald B. H Tan, Crystallization and Particle Science, Institute of Chemical & Engineering Sciences, 1 Pesek Road, Jurong Island, Singapore, 627833, Singapore
Mechanistic Model for the Effect of Molecular Imposters on the Shape of Molecular Organic Crystals
Jacob P. Sizemore and M. F. Doherty, University of California Santa Barbara, Department of Chemical Engineering, Santa Barbara, CA 93106
Precise Tailoring of the Crystal Size Distribution by Optimal Seeding Time Profiles
Nicholas Kee, Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117576, Singapore, Xing Yi Woo, Genome Institute of Singapore, 60 Biopolis Street, #02-01, Genome, Singapore, 138672, Singapore, Reginald B. H Tan, Crystallisation and Particle Science, Institute of Chemical & Engineering Sciences, 1 Pesek Road, Jurong Island, Singapore, 627833, Singapore and Richard D. Braatz, Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Box C-3, 293 Roger Adams Laboratory, Urbana, IL 61801-3602
Development and Scale-up of a Seeded Acidic Co-Addition Crystallization
Adam S. Butterbaugh, Kevin D. Seibert and Paul C. Collins, Eli Lilly & Co., 1400 W. Raymond St., B110, Indianapolis, IN 46221
Systematic Design of Supersaturation Controlled Crystallization Processes
Zoltan K. Nagy1, Erum AAmir2 and Chris Rielly2, (1)Chemical Engineering Department, Loughborough University, Loughborough, LE11 3TU, England, (2)Loughborough University, Loughborough, LE11 3TU, England

Food, Pharmaceutical & Bioengineering Division