Wednesday, November 7, 2007: 12:30 PM-3:00 PM
M - Salon I (Marriott Salt Lake City-Downtown)

Topical I: Pharmaceutical Engineering for the 21^st Century (TI)

#409 - Continuous Processing with Process Analytical Technology (TI016)
Continuous processing has long been well established in various industries including the food, dairy, and chemical industry because large-volume productions are often found in these industries. Despite the many advantages of continuous processing as compared with batch processing such as low operating and capital costs, consistent quality, ease of automation, reduced scale-up and streamlined process development, batch processing has been traditionally used in industries where low-volume, sophisticated products demanding stringent quality attributes are manufactured (e.g. pharmaceutical industry). With the advances in process analytical technology, which is adopted in the pharmaceutical industry as part of the PAT initiative, in equipment design and automation, as well as in process modeling and control, continuous processing is becoming a feasible option even for the manufacture of relatively low-volume products. Papers that enhance our understanding of continuous particulate processes such as blending, granulation, spray drying, milling, roller compaction, etc. are invited from both academia and all sectors of industry. They can be experimental, theoretical, and/or computational. Although pharmaceutical applications will be given special consideration, the session is intended to serve as a venue for sharing fundamental, continuous particulate processing knowledge across a multitude of industries. Those papers that consider process analytical technology and/or modeling tools toward characterizing continuous processes or controlling them are especially welcome.
Chair:Ecevit Bilgili
CoChair:Mark Bumiller
CoSponsor(s):Particle Production and Characterization (03a)
Pharmaceuticals (15b)
12:30 PM Welcoming Remarks
12:35 PM409aContinuous Powder Blending For Pharmaceutical Applications
Michael Gentzler, Ecevit Bilgili, Brit L. Rudeen, Mano Ramasamy, Steve J. Heidel
12:55 PM409bModel Predictive Control on Roller Compaction for Pharmaceutical Manufacturing
Shuo-Huan Hsu, Girish Joglekar, Gintaras V. Reklaitis, Venkat Venkatasubramanian
1:15 PM409cExperimental Study And Computational Modeling Of Continuous Powder Mixing Processes
Patricia M. Portillo, Marianthi G. Ierapetritou, Fernando J. Muzzio
1:35 PM409dDetermination Of Granulation Growth Rates: An Evaluation Between Fbrm And Sieve Analysis
Kevin Macias, M. Teresa Carvajal
1:55 PM Break
2:00 PM409eEffect of Stirrer Design on the Homogeneity of a Pharmaceutical Powder Mixture
Henri Berthiaux, Cendrine Gatumel, Jean-Louis Dirion
2:20 PM409fApplication Of In-Line Transmission Nir For Improved Process Understanding And Control Of A Continuous Mixing Process
Gregory M. Troup, John P. Higgins, Craig A. Mckelvey, Michael Lowinger, Jeff S. Ko, Luke R. Schenck, Robert F. Meyer, Brit L. Rudeen
2:40 PM409gContinuous Dry Powder Blending: Effect of Process Variables and Material Properties
Lakshman Pernenkil, Farzad J. Yazdi, Jason Whittaker, Charles Cooney

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