Thermal swing adsorption has been developed as honeycomb rotor adsorbers and applied to dehumidification of air, removal of VOC and so on. It was limited to a system of single component to purify the bulk inert gas. In the present paper, we discuss a binary mixture where a more adsorbable component P and a less adsorbable component N diluted in the bulk inert gas are to be separated from each other. A honeycomb adsorbent rotor is divided into four sections as shown in Fig.1 and experiences four successive steps: Adsorption of P-component (PA step), Adsorption of N-component (NA step), Desorption of P-component (PD step) and Desorption of N-component (ND step). The P-rich and N-rich products, respectively, are obtained in the P- and N-stream after the PD- and PA-steps. A preliminary discussion is made on a continuous moving bed for a simple case of instantaneous thermal response and independent linear isotherms. The slope of operating line in PA step has to be greater than the adsorption coefficient of NA isotherm to achieve the preferential adsorption of P-component in the PA step by depressing the N-component adsorption. Similar discussion leads to relationships between the slope of operating lines and adsorption coefficients for successful separation of P and N. This criterion was found to be applied to the cross flow moving bed that is an operation mode of the usual honeycomb rotor adsorbent. Thus, the optimal operating condition was derived for circulating flow rate Q and step time. The same idea will be extended to more complicated cases such as additional withdrawal of inert gas and nonlinear isotherm.