This presentation is based on our experience in transformation of Design curriculum over the past two decades at institutions the author have been affiliated with and focus on the challenges associated with integrating various elements of product and process design within the projects and curriculum. Projects from diverse emerging areas in microelectronics, fuels cells, targeted delivery products, biomedical devices, and novel material are used. The utility of core processing technologies in the design of several different products will be illustrated using products such as self heating/cooling products, sustainable energy based products such as green sail boats, and targetted delivery products. The impact of the product design on the curriculum including the efforts in recent NSF Spiral Curriculum Reform Implementation grant at the University of South Florida will also be discussed. The selected projects involve novel products that has been introduced to market by our industrial partners. Uncertainty analysis, microeconomics, and Computational Fluid Dynamics are heavily relied on in the projects.