| Monday, 13 November 2006: 3:15 PM-5:45 PM | |||
| Union Square 25 (Hilton San Francisco) | |||
Topical 5: Pilot Plant Design and Optimization (T5) | |||
| #151 - Strategies in Biopharmaceutical Scale-up & Pilot Plants (T5003) | |||
| While reducing the timelines to market is still a challenge, adopting efficient scale-up and technology transfer strategies in the biopharmaceutical industry is critical. In this race to commercialize new technology, or to improve existing technology, it is widely accepted that pilot plants play a key role in the overall process development scheme. Therefore, this session is particularly interested in topics that include, but are not limited to, scale-up approaches and troubleshooting for upstream and downstream processes, unique technology transfer strategies, design and operation of pilot plants, case studies on processes that are scaled-up in pilot plants that demonstrate a unique team approach and delivery under aggressive timelines and budget limitations. | |||
| Chair: | Nihal Tugcu | ||
| CoChair: | Jeanette Beard | ||
| CoSponsor(s): | Pilot Plants (12b) Pharmaceuticals (See also Topical 2) (15b) Topical 2: Discover, Development and Delivery of Medicines (T2) | ||
| 3:15 PM | Introductory Remarks | ||
| Part 1 | |||
| 3:20 PM | 151a | Cell Culture Scale-up and Technology Transfer for 12,000 L-Scale Therapeutic Antibody Manufacturing John Fann, John Ponzo, Ziran Sun, Seshu Tummala, Clara Teijido, Min Wan, George Avgerinos | |
| 3:41 PM | 151b | Strategy to Fit a Downstream Purification Platform for an Early Stage Development, Therapeutic Protein into an Existing Pilot Plant Francis M. Torres, Nguyen V. Ly | |
| 4:02 PM | 151c | The Role of Process Modeling in Bioprocess Development and Technology Transfer Charles Siletti, Demetri P. Petrides | |
| 4:23 PM | 151e | Multi-Dimensional Model for Prediction and Scale-up of Lyophilization Pavol Rajniak, Jiri Placek, Joseph Schaller, Rajiv Mahajan, Rey Chern | |
| 4:44 PM | 151f | Scale up of Fluid Mixing Parameters in Bio-Pharmaceutical Processes James Y. Oldshue | |
| 5:05 PM | 151g | From Petrochemicals to Pharmaceuticals: Rapid Scale-up of Penicillin by an Academia-Industry Consortium Including Shell Development Company during World War II Joseph B. Powell | |
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