Metabolic and cellular engineering has been successfully performed to develop microbial strains that are capable of producing chemicals, proteins, and unnatural polymers. Design and optimization of the metabolic and gene regulatory networks are important to develop a microbial strain suitable for their industrial production. Systems metabolic engineering approaches can be taken to improve the strain from the level that has typically been achieved by traditional metabolic engineering to a next level by considering the cell as a whole. In addition to optimizing the cell using inherent and heterologous metabolism found in nature, artificial enzymes/reactions can be developed to establish new pathways and networks leading to the formation of new products including unnatural products. In this lecture, strategies taken to develop microbial strains capable of producing chemicals and materials will be described with relevant case studies carried out in our lab. [This work was supported by Korean Systems Biology Research Project from the Ministry of Education, Science and Technology. Further supports by LG Chem Chair Professorship and Microsoft are appreciated.]

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