Fidelity and Speed of Signal Transmission Limited by Cellular Noise
Chee Meng Tan, Faisal Reza and Lingchong You, Biomedical Engineering & Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708 |
Regulation of Cellular Apoptosis by Palmitic Acid and Tnf-Alpha: Involvement of Signal Transduction Pathways from Pkr to Bcl-2
Xuerui Yang, Department of Chemical Engineering and Materials Science, Michigan State University, 2527 Engineering Building, East Lansing, MI 48823 and Christina Chan, Chemical Engineering and Material Science, Michigan State University, 2527 Engineering Building, East Lansing, MI 48824 |
Analyzing the Stress Response of Yeast
Ping Xu1, David Raden1, Scott Hildebrandt2, Francis J. Doyle III2 and Anne Skaja Robinson1, (1)University of Delaware, 259 Colburn Laboratory, Department of Chemical Engineering, Newark, DE 19716, (2)Department of Chemical Engineering, University of California - Santa Barbara, Santa Barbara, CA 93101-9611 |
Noise Regulation by Quorum Sensing
Dennis P. Tu, Biomedical Engineering, Duke University, 101 Science Dr., CIEMAS RM 2397, Durham, NC 27710, Jiwon Lee, Duke University, 101 Science Dr., CIEMAS RM 2397, Durham, NC 27710 and Lingchong You, Biomedical Engineering & Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708 |
Multi-Scale Models for Gene Networks
Yiannis Kaznessis, Chemical Engineering and Materials Science, University of Minnesota, 151 Amundson Hall, 421 Washington Ave SE, Minneapolis, MN 55454 |
Prediction of Carbohydrate-Protein Gibbs Free Energies of Binding by Automated Docking
Anthony D. Hill and Peter J. Reilly, Chemical and Biological Engineering, Iowa State University, 2114 Sweeney Hall, Ames, IA 50011-2230 |
The Design of Potent Biomimetic Anthrax Toxin Inhibitors
Prakash Rai1, Arundhati Saraph1, Saleem Basha1, Vincent Poon2, Randolph Ashton1, Jeremy Mogridge2 and Ravi S. Kane1, (1)Rensselaer Polytechnic Institute, 110 Eighth Street, Troy, NY 12180, (2)University of Toronto, 1 King’s College Circle, Toronto, ON M5S1A8, Canada |
Effect of Autoinducer Pai2 in P.Aeruginosa Biofilm Development :Wild Type and Rhli (-)Mutant
Lieke Riadi; JY Hu, WJ Ng, Department of Chemical Engineering,The University of Surabaya, Environmental Sciience Engineering ,National University of Singapore, Jl.Raya Kalirungkut, Surabaya, Indonesia |
In Silico Analysis of Cell Fate Patterning during Development
Claudiu A. Giurumescu, California Institute of Technology, 1200 E. California Blvd, MC 210-41, Pasadena, CA 91125 and Anand R. Asthagiri, Chemical Engineering, California Institute of Technology, 1200 E. California Blvd MC 210-41, Pasadena, CA 91125 |
Transcriptional Analysis of the Genome-Wide Response of Leukocytes in an in Vivo Human Model of Systemic Inflammation
Panagiota Foteinou1, Kelly Horn2, Eric Yang1, Steven Calvano3, Stephen Lowry3 and Ioannis Androulakis1, (1)Biomedical Engineering, Rutgers University, Piscataway, NJ 08854, (2)Bioengineering Department, Rice University, Houston, TX 77005, (3)Department of Surgery, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ 08901 |
Cellular Hydrogen Peroxide Removal Shows Dependency on Effective GPx Activity: Mathematical Insight into Observed in-vivo Behavior
Chin F. Ng1, Freya Q. Schafer2, Garry R. Buettner2 and Victor G. J. Rodgers1, (1)Bioengineering, University of California, Riverside, A242 Bourns Hall, Riverside, CA 92521, (2)Free Radical and Radiation Biology Program & ESR Facility, University of Iowa, Carver College of Medicine, EMRB 68, Iowa City, IA 52242 |
Rule-Based Modeling of Biochemical Networks Based on Protein Interactions: Theory, Software, and Applications
James Faeder, Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545 |
Mab Production Influencing Compounds and How They Influence Protein Transcription, Translation, and Secretion
Tiffany D. Rau, Chemical Engineering Department, Vanderbilt University, VU Station B #351604, 2301 Vanderbilt Place, Nashville, TN 37235-1604 and R. Robert Balcarcel, Cell and Tissue Technologies, BD, 2350 Qume Drive, San Jose, CA 95131-1807 |
Chemical Complementation: Protein Engineering through Genetic Selection
Donald F. Doyle1, Bahareh Azizi2, Priyanka Rohatgi2, Lauren J. Schwimmer3 and H. Trent Spencer4, (1)Georgia Institute of Technology, 315 FERST DR. #3432, Atlanta, GA 303332, (2)School of Chemistry and Biochemistry, Georgia Institute of Technology, 315 FERST DR. #3432, Atlanta, GA 303332, (3)The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, CA 92037, (4)Pediatric Hematology/Oncology, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA 30322 |
Modeling the Interaction of Two Major Extrinsic Pathways and Their Output to the Granule Cells of the Hippocampus of the Mammalian Brain
Angelika Dimoka1, Spiros H. Courellis2, Vasilis Z. Marmarelis2 and Theodore W. Berger2, (1)Department of Bioengineering, University of California, Riverside, Bourns College of Engineering, University of California, Riverside, Riverside, CA 92521-0144, (2)Biomedical Engineering, University of Southern California, Los Angeles, CA 90089 |
Metabolic Reconstruction and Modeling of Nitrogen Fixation in Rhizobium Etli
Osbaldo Resendis-Antonio1, Jennifer L. Reed2 and Bernhard O. Palsson2, (1)Bioengineering department, University of California San Diego, 417 Powell-Focht Bioengineering Hall, 9500 Gilman Drive., La Jolla, CA 92093-0412, (2)University of California San Diego, 417 Powell-Focht Bioengineering Hall, 9500 Gilman Drive., La Jolla, CA 92093-0412 |
Parsing the Crosstalk between Prominent Oncogenic Signaling Pathways
Nicholas A. Graham, California Institute of Technology, 1200 E. California Blvd, MC 210-41, Pasadena, CA 91125 and Anand R. Asthagiri, Chemical Engineering, California Institute of Technology, 1200 E. California Blvd MC 210-41, Pasadena, CA 91125 |
Metabolic Modeling of Central and Xenobiotic Metabolism in Hepatocytes
Charles M. Roth1, Hong Yang2, Stephen A. Guzikowski3 and Marianthi Ierapetritou3, (1)Chemical and Biochemical Engineering and Biomedical Engineering, Rutgers University, 98 Brett Road, Piscataway, NJ 08854, (2)Department of Chemical and Biochemical Engineering, Rutgers, the State University of New Jersey, 98 Brett Road, Piscataway, NJ 08854, (3)Chemical and Biochemical Engineering, Rutgers University, 98 Brett Road, Piscataway, NJ 08854 |
Metabolic Systems Cost-Benefit Analysis
Ross P. Carlson, Chemical and Biological Engineering, Montana State University, 315 Cobleigh Hall, Bozeman, MT 59717 |
Directed Evolution by in Vitro Coevolution
Huimin Zhao, Chemical & Biomolecular Engineering, University of Illinois at Urbana-Champaign, 215 RAL, Box C-3, MC-712, 600 S. Mathews Ave., Urbana, IL 61801 and Zhilei Chen, University of Illinois at Urbana-Champaign, 215 RAL, Box C-3, MC-712, 600 S. Mathews Ave., Urbana, IL 61801 |
High Affinity Fn3 Domains Using Loop Length Diversity and Population Maturation
Benjamin J. Hackel and K. Dane Wittrup, Chemical Engineering, Massachusetts Institute of Technology, 50 Ames Street, E19-563, Cambridge, MA 02139 |
Toward Protein Misfolding Disease Therapeutics
Laura Segatori and Jeffrey W Kelly, Chemistry, The Scripps Research Institute, 10050 N. Torrey Pines Road, La Jolla, CA 92037 |
19f NMR as a Probe of Protein Structure and Conformational Changes in Nitrogen Regulatory Protein C from Salmonella Typhimurium
Jared T. Hammill, Chemistry, Franklin and Marshall College, 2702 Sage Wood Dr, Newtown Square, PA 19073 and Dr Ryan Mehl, Chemistry, Franklin and Marshall College, PO Box 3003, Lancaster, PA 17604 |
Determination of Protein Interaction Subnetworks in Shewanella Oneidensis Using Endogenous and Exogenous Affinity Isolation Methods
Brian S. Hooker1, Deanna L. Auberry1, Kenneth J. Auberry1, William R. Cannon1, Yuri A. Gorby1, Eric A. Hill1, Vladimir Kery1, Chiann-Tso Lin1, Eric A. Livesay1, Priscilla A. Moore1, Ronald J. Moore1, Richard D. Smith1, Kristin D. Victry1, H. Steven Wiley1, Dale A. Pelletier2, Michelle V. Buchanan2, Linda J. Foote2, Gregory B. Hurst2, Stephen J. Kennel2, Trish K. Lankford2, Tse-Yuan S. Lu2, Cathy K. McKeown2 and Denise Schmoyer2, (1)Pacific Northwest National Laboratory, 902 Battelle Blvd., K4-12, Richland, WA 99354, (2)Oak Ridge National Laboratory, Oak Ridge, TN 37381 |
Manipulation and Kinetic Analysis of Crosstalk between Pi 3-Kinase/Akt and Ras/Erk Signal Transduction Pathways
Chun-Chao Wang, Chemical & Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695 and Jason Haugh, Chemical & Biomolecular Engineering, North Carolina State University, Box 7905, Engineering Bldg. I, 911 Partners Way, Raleigh, NC 27695-7905 |
Rule-Based Computational Modeling of Modular Signaling Protein Function: Focus on Shp2
Dipak Barua, Chemical & Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695 and Jason Haugh, Chemical & Biomolecular Engineering, North Carolina State University, Box 7905, Engineering Bldg. I, 911 Partners Way, Raleigh, NC 27695-7905 |
Dynamics of Pi3k- and Pkc-Dependent Motility Processes during Cell Spreading on Adhesive Surfaces
Michael Weiger, Chemical & Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695-7905 and Jason Haugh, Chemical & Biomolecular Engineering, North Carolina State University, Box 7905, Engineering Bldg. I, 911 Partners Way, Raleigh, NC 27695-7905 |
Intracellular Signaling Networks in the Immune Response: Pathways Activated by Interleukin-2 and -4 Receptors and Their Roles in T Cell Proliferation
Kristen Comfort, Chemical & Biomolecular Engineering, North Carolina State University, Box 7905, Raleigh, NC 27695-7905 and Jason Haugh, Chemical & Biomolecular Engineering, North Carolina State University, Box 7905, Engineering Bldg. I, 911 Partners Way, Raleigh, NC 27695-7905 |
First Principle Modeling of Free Energy Changes of Point Mutations: a Modest Triumph of Knowledge in the Information Age
Marta Bueno1, Javier Sancho2 and Carlos Camacho1, (1)Computational Biology, University of Pittsburgh, 3501 Fifth Ave Rm 3077, Pittsburgh, PA 15213, (2)Biochemistry, University of Zaragoza, Zaragoza, Spain |
Understanding Protein Transcytosis to Engineer Efficient Biomolecular Therapeutics
Pankaj Karande, Chemical Engineering, Massachusetts Institute of Technology, E19-563, Cambridge, MA 02139 and K. Dane Wittrup, Chemical Engineering and Biological Engineering, Massachusetts Institute of Technology, E19-551, Cambridge, MA 02139 |
3dm: a Tool for Assigning Function to Amino Acids
Henk-Jan Joosten, Fungal Genomics, Wageningen University, Dreijenlaan 2, Wageningen, 6536CP, Netherlands |
Sequence Elements Determine Protein Stability in a Synthetic Cytochrome P450 Family
Yougen Li and Frances H. Arnold, Chemistry & Chemical Engineering, California Institute of Technology, Pasadena, CA 91125 |
Short-Chain Chondroitin Sulfates Enhance in Vitro Chondrocytic Induction from Mesenchymal Stem Cells on Collagen Scaffold
Chih-Sheng Ko and I-Ming Chu, Chemical Engineering, Natioanl Tsing Hua University, 101 Kuang Fu Road, Hsinchu, Taiwan |
Improving the Growth Rate of Escherichia Coli Dh5alpha by Directed Evolution of Chaperonin
Jae-Hun Lee1, Sun-Gu Lee2, Byung-Gee Kim1, Mi-Ae Heo2 and Yu Jin Kim2, (1)Interdisciplinary Program for Biochemical Engineering and Biotechnology, Seoul National University, Seoul, 151-742, South Korea, (2)Department of chemical engineering, Pusan National University, Busan, 609-735, South Korea |
Comparison of Serological Survey of Influenza Viruses on Pig Farm Workers by Hemagglutination Inhibition and Biochips
Yin-Mei Chiung1, Jenn-Han Chen2, Chen-Wen Yao3, Yu-Tien Liu4, Wen-Bou Lin4, Da-Guan Hu5, Ching-Nan Chang6 and Chiu-Jong Chen7, (1)Department of Microbiology and Immunology, National Defense Medical Center, No.161,Section 6,Min-Chuan East Road ,Taipei 114, Taiwan, Republic of China, Taipei, 114, Taiwan, (2)School of Dentistry, National Defense Medical Center, Taipei, Taiwan, (3)School of Public Health, National Defense Medical Center, Taipei, Taiwan, (4)Microbiology & Immunology, National Defense Medical Center, No.161,Section 6,Min-Chuan East Road ,Taipei 114, Taiwan, Republic of China, Taipei, 114, Taiwan, (5)Division of Animal Medicine, Animal Technology Institute Taiwan, Chu-Nan, 350, Taiwan, (6)Animal Technology Institute Taiwan, Miaou-Li, Taiwan, (7)Division of Medicine, Institute of Occupational Safety and Health, Taipei, Taiwan |
Suppression of Calcium Signaling through Conjugation of 2,4-Toluene Diisocyanate Onto P2x Receptor in Hela Cell Analyzed by Lc- Esi-Q-Tof Mass Spectrometry
Yin-Mei Chiung1, Pei-Shan Liu2, Li-Ting Tsai3, Yi-Yun Kao4, Jun-Bou Lin4, Tung-Shen Shih5 and Yu-Tien Liu3, (1)Department of Microbiology and Immunology, National Defense Medical Center, No.161,Section 6,Min-Chuan East Road ,Taipei 114, Taiwan, Republic of China, Taipei, 114, Taiwan, (2)Department of Microbiology, Soochow University, Taipei, Taiwan, (3)Microbiology & Immunology, National Defense Medical Center, No.161,Section 6,Min-Chuan East Road ,Taipei 114, Taiwan, Republic of China, Taipei, 114, Taiwan, (4)Microbiology, Soochow University, Taipei, Taiwan, (5)Institute of Occupational Safety and Health, Taiwan |
Structure Prediction of Engineered Domain-Insert Protein Switches
Monica Berrondo, Marc Ostermeier and Jeffrey J. Gray, Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218 |
Dynamic Strength of Molecularly Bonded Surfaces
fang Li, Mechanical Science and Engineering, University of Illinois at Urbana and Champaign, Rm 19, RAL, 600 S. Mathews, Urbana, IL 61801 and Deborah Leckband, Chemical and Biomolecular Engineering, University of Illinois at Urbana and Champaign, Rm 19, RAL, 600 S. Mathews, Urbana, IL 61801 |
Increased Drug Carrier Efficacy of Transferrin Conjugates through Inhibition of Iron Release
Bert J. Lao1, Wen-Lin P. Tsai1, Foad Mashayekhi1, Edward A. Pham1, Anne B. Mason2 and Daniel T. Kamei1, (1)Bioengineering, UCLA, 420 Westwood Plaza, Los Angeles, CA 90095, (2)Biochemistry, University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405 |
Integrating Statistical Thermodynamics into a Cell-Level Model to Aid in Engineering Fc
Victor Z. Sun and Daniel T. Kamei, Bioengineering, UCLA, 420 Westwood Plaza, Los Angeles, CA 90095 |
Construction and Engineering of Positive Feedback Loops
Daniel J. Sayut, Yan Niu and Lianhong Sun, Chemical Engineering, University of Massachusetts Amherst, 159 Goessmann Lab, 686 North Pleasant St, Amherst, MA 01003 |
An Antibody-Activated Variant of Beta-Glucuronidase
Ichiro Matsumura, Biochemistry, School of Medicine, Emory University, Atlanta, GA 30322 and Melissa Geddie, Biochemistry, Emory University, Atlanta, GA 30322 |
Carbon Dioxide Assimilation by Metabolically Engineered Escherichia Coli
Ichiro Matsumura1, Dina Greene2 and Monal Parikh2, (1)Biochemistry, School of Medicine, Emory University, Atlanta, GA 30322, (2)Biochemistry, Emory University, Atlanta, GA 30322 |
A Platform for Directed Evolution of Neurotrophins
Eric Shusta and Michael L. Burns, University of Wisconsin, 1415 Engineering Drive, Madison, WI 53715 |
Electrically-Induced Mechanical Force Generation by Cellular Plasma Membranes
Bahman Anvari, Bioengineering, University of California, Riverside, Bourns Hall, Room A227, Riverside, CA 92507, Feng Qian, Bioengineering, Rice University, 6100 Main St., MS-142, Houston, TX 77005 and William E. Brownell, Department of Otorhinolaryngology & Communicative Sciences, Baylor College of Medicine, NA 505, Houston, TX 77030 |
Model Driven Design of Antimicrobial Peptides
Yiannis N. Kaznessis, Chemical Engineering and Materials Science, University of Minnesota, 151 Amundson Hall, 421 Washington Ave SE, Minneapolis, MN 55454, Himanshu Khandelia, Chemical Engineering and Materials Science, University of Minnesota, #112, 421, Washington Avenue SE, Minneapolis, MN 55455 and Allison Langham, Chemical Engineering and Materials Science, University of Minnesota, 117 Pleasant St SE, Walter Library 488, Minneapolis, MN 55455 |
A New Platform for Engineering High-Affinity Synthetic Antibodies Based on a Bacterial Hitchhiker Mechanism
Dujduan Waraho, Chemical and Biomolecular Engineering, Cornell University, 120 Olin Hall, Cornell University, Ithaca, NY 14850 and Matthew P. DeLisa, Department of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14850 |
Molecular Engineering of Soluble Proteins in the Cytoplasm of Escherichia Coli Using the Tat Machinery
Adam C. Fisher, Cornell University, 304 Olin Hall, Ithaca, NY 14853 and Matthew P. DeLisa, Department of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14850 |
Transcriptional Regulation of Cell Cycle Regulators in Mediating Mesenchymal Stem Cell Proliferation and Differentiation
Linxia Zhang1, Tim Howes1, Neil Wright2 and Christina Chan1, (1)Chemical Engineering and Material Science, Michigan State University, 2527 Engineering Building, East Lansing, MI 48824, (2)Mechanical Engineering, Michigan State University, 2555 Engineering Building, East Lansing, MI 48824 |
Permissive Topologies for Fusion of Maltose Binding Protein and the Green Fluorescent Protein
Allen Bosley and Marc Ostermeier, Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21227 |
Directed Evolution of Cytochrome P450 Bm3 for Selective Hydroxylation of Gaseous Alkanes
Michael M. Y. Chen1, Rudi Fasan2 and Frances H. Arnold2, (1)Chemical Engineering, California Institute of Technology, 210-41, Pasadena, CA 91125, (2)Chemical Engineering, California Institute of Technology, 1200 E California Blvd, Pasadena, CA 91125 |
Design of a Protein-Solid Surface Interface
David Masica1, Kosta Makrodimitris2, Eleanor Glifort2 and Jeffrey Gray3, (1)Program in Molecular and Computational Biophysics, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218, (2)Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218, (3)Chemical and Biomolecular Engineering, Program in Molecular and Computational Biophysics, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218 |
Non-Lithographically Fabricated Microfluidic Devices for Sensor Applications
Brent Millare, Marlon Thomas, Madison Holsinger and Valentine I. Vullev, Department of Bioengineering, University of California, Riverside, Bourns College of Engineering, Riverside, CA 92521 |
Creation of Thermostable Enzyme Based on Thermophilic Scaffold
Jin Ryoun Kim, Chemical and Biological Engineering, Polytechnic University, Brooklyn, NY 11201, Loren L. Looger, Plant Biology, Stanford University, Stanford, CA 94305 and Marc Ostermeier, Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218 |
Optimal Conditions for Expedient Non-Lithographic Fabrication of Poly(Dimethylsioloxane) Based Microfluidic Devices
Brent Millare1, Madison Holsinger2, Marlon Thomas2, Amy Ferreira2 and Valentine Vullev2, (1)Department of Bioengineering, University of California, Riverside, Bourns School of Engineering, Riverside, CA 92521, (2)University of California, Riverside, Bourns School of Engineering, Riverside, CA 92521 |
Project Management and Design of Bio-Production Plants--Practical Lessons Learned
Satish Almaula, Exponent, 149 Commonwealth Drive, Menlo Park, CA 94025 |
A Novel Data Mining Method to Identify Assay-Specific Signatures in Functional Genomic Studies
Ramon Gonzalez1, Derrick K. Rollins2, Abhishek Murarka3, Dongmei Zhai4, Alrica Joe4 and Jack Guidarelli4, (1)Chemical and Biomolecular Engineering, Rice University, MS-362, P.O. Box 1892, Houston, TX 77251-1892, (2)Iowa State University, 2114 Sweeney, Ames, IA 50011, (3)Chemical & Biomolecular Engineering, Rice University, MS-362, P.O. Box 1892, Houston, TX 77251-1892, (4)Chemical & Biological Engineering, Iowa State University, 2114 Sweeney, Ames, IA 50011 |
A Genetic Selection for Protein Folding and Solubility in the Bacterial Periplasm
Thomas J. Mansell and Matthew P. DeLisa, Department of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14850 |
Charge Transfer through an Amide Bond in a Photoactive Dyad
Amy Ferreira1, Wei Xia1, Jiandi Wan2, Guilford Jones II3 and Valentine I. Vullev1, (1)Department of Bioengineering, University of California, Riverside, Bourns College of Engineering, Riverside, CA 92521, (2)Division of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, Cambridge, MA 02138, (3)Department of Chemistry and Photonics Center, Boston University, 590 Commonwealth Avenue, Boston, MA 02215 |
Biofunctional Coatings on Silicon-Based Substrates
Marlon Thomas1, Jiandi Wan2 and Valentine I. Vullev1, (1)Department of Bioengineering, University of California, Riverside, Bourns College of Engineering, Riverside, CA 92521, (2)Division of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, Cambridge, MA 02138 |
Impact of Target Mrna Structure on Silencing Efficiency and Immune Stimulation in RNA Interference
Joseph A. Gredell, Department of Chemical Engineering and Materials Science, Michigan State University, 2527 Engineering Building, East Lansing, MI 48824 and S. Patrick Walton, Department of Chemical Engineering and Materials Science, Michigan State University, 3249 Engineering Building, East Lansing, MI 48823 |
Circular Permutation of Tem1 ß-Lactamase Improves Catalytic Activity
Manu Kanwar, Gurkan Guntas and Marc Ostermeier, Chemical and Biomolecular Engineering, Johns Hopkins University, 221 Maryland Hall,, 3400 North Charles Street, Baltimore, MD 21218 |
The Role of Dynamics and Electrostatics in Biomolecular Interactions: Study and Design of Immune System Proteins, Regulators and Inhibitors
Dimitrios Morikis1, Li Zhang2 and Buddhadeb Mallik1, (1)Bioengineering, University of California, Riverside, Riverside, CA 92506, (2)Chemistry, University of California, Riverside, Riverside, CA 92506 |
Design of a Human Heavy Chain Variable Domain (Vh) Scaffold for the Construction of Synthetic Phage-Displayed Vh Libraries
Pierre Arnaud Barthelemy1, Helga Raab2, Brent Appleton1, Christian Wiesmann1 and Sachdev Sidhu1, (1)Protein Engineering, Genentech, Inc., 1 DNA Way, Mail Stop 27, South San Francisco, CA 94080, (2)Protein Chemistry, Genentech, Inc., 1 DNA Way, Mail Stop 63, South San Francisco, CA 94080 |
A Systems Biology Approach to HIV-1 Gene Expression
John C. Burnett1, Denise M. Wolf2, Adam P. Arkin3 and David V. Schaffer1, (1)Chemical Engineering, University of California at Berkeley, Department of Chemical Engineering, 201 Gilman Hall, Berkeley, CA 94720-1462, (2)Physical Biosciences, Lawrence Berkeley National Laboratories, Berkeley, CA 94720-1462, (3)Bioengineering, University of California at Berkeley, Berkeley, CA 94720-1462 |
Efficient Synthesis of Simvastatin Using Whole-Cell Biocatalysis
Yi Tang, Chemical and Biomolecular Engineering, University of California at Los Angeles, 420 Westwood Plaza, 5667 Boelter Hall, Los Angeles, CA 90095 and Xinkai Xie, Chemical and Biomolecular, University of California at Los Angeles, 420 Westwood Plaza, 5667 Boelter Hall, Los Angeles, CA 90095 |
pH-Controlled Fluorescence Resonance Energy Transfer as Simple and Quantitative Assay Tool for Engineering of Antimicrobial Peptides
Young Soo Kim and Hyung Joon Cha, Chemical Engineering, POSTECH (Pohang University of Science and Technology), Pohang, 790-784, South Korea |
Revolutionary Recombinant Hybrid Mussel Adhesive Protein Fp-151
Hyung Joon Cha, Dong Soo Hwang, Youngsoo Gim and Hyo Jin Yoo, Chemical Engineering, POSTECH (Pohang University of Science and Technology), Pohang, 790-784, South Korea |
Production of Recombinant Glycoprotein with Low Levels of N-Glycoylneuraminic Acids in Cho Cells by Co-Expressing Cmp-Sialic Acid Transporter
Dong Gyun Kang and Hyung Joon Cha, Chemical Engineering, POSTECH (Pohang University of Science and Technology), Pohang, 790-784, South Korea |
Screening and Affinity Maturation of Vegf-Binding Peptides
Sophia A. Kenrick and Patrick S. Daugherty, Chemical Engineering, University of California, Santa Barabara, Engineering II, Room 3357, Santa Barbara, CA 93106-5080 |
Directed Evolution of Intein Splicing Activity by Phage Display
Kaori Hiraga1, Victoria Derbyshire1, Georges Belfort2 and Marlene Belfort1, (1)Wadsworth Center, NYS Department of Health, 150 New Scotland Avenue, Albany, NY 12208, (2)Howard P. Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, 110 8th st, Troy, NY 12180-3590 |
Chemically Engineered Polyallylamine Nanoparticles : an Efficient Gene Delivery System
Atul Pathak1, Anita Aggrawal1, Soma Patnaik1, Archana Swami1, Pradeep Kumar1, S.P. Vyas2 and Kailash C. Gupta1, (1)Institute of Genomics and Integrative Biology, Mall road, Delhi University Campus, Delhi, 110007, India, (2)Department of Pharmaceutical Sciences, Dr. Harisingh Gour University, Sagar, Sagar MadhyaPradesh, 470003, India |
Nanoscale Biomolecular Devices: Integration of Biomolecules into Inorganic Framework Materials
Millicent A. Firestone1, Brian Reiss1, Leonidas Ocola2, Orlando Auciello1 and Deborah Hanson3, (1)Materials Science, Argonne National Laboratory, 9700 South Cass Ave, Argonne, IL 60439, (2)Center for Nanoscale Materials, Argonne National Laboratory, 9700 S. Cass Avenue, Argonne, IL 60439, (3)Biosciences, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439 |
Fluorescence Detection of Glucose/Glutamine Based on Glucose/Glutamine Binding Protein Immobilized on Dextran Modified Glass Capillary
Debora W. Lin, Thomas Hsu, Cameron Bardliving, Caroline Dehart, Amelita Bartolome, Govind Rao and Leah Tolosa, Biochemical and Chemical Engineering, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250 |
Discovery and Application of a Bright Blue Fluorescent Protein Isolated from Structurally Targeted Library Screening
Marco A. Mena1, Thomas P. Treynor2, Stephen L. Mayo2 and Patrick S. Daugherty1, (1)Department of Chemical Engineering, UC Santa Barbara, Engineering II Rm 3357, Santa Barbara, CA 93106-5080, (2)Division of Biology, Division of Chemistry and Chemical Engineering, California Institute of Technology, Caltech 114-96, 1200 E. California Blvd, Pasadena, CA 91125-9600 |
Self-Assembled Protein Polymers for the Development of Nanostructured Biomaterials
Wesley D. Marner II, University of California, Berkeley, 201 Gilman Hall, Berkeley, CA 94720, Jay D. Keasling, Chemical Engineering, University of California, Berkeley, Berkeley, CA 94720 and Susan J. Muller, Chemical Engineering, University of California at Berkeley, Berkeley, CA 94720 |
A Synthetic Escherichia Coli Predator-Prey System
Frederick Balagaddé1, Jun Ozaki2, Cynthia H. Collins3, Matthew Barnet3, Peter Blais4, Frances H. Arnold5, Stephen Quake4 and Lingchong You2, (1)Bioengineering, Stanford University, 318 Campus Drive, Stanford, CA 94305, (2)Biomedical Engineering, Duke University, Durham, NC 27705, (3)Chemistry & Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, (4)Bioengineering, Duke University, Durham, NC 27705, (5)Chemical Engineering, California Institute of Technology, MC 210-41, Pasadena, CA 91125 |
Directed Evolution of Conformational Changes in Peptides
Scott Banta, Mark Blenner and Karuppiah Chockalingam, Chemical Engineering, Columbia University, 500 W 120th St, New York, NY 10027 |
A Novel Bacterial Approach for Detecting Protein-Protein Interactions Based on the Twin-Arginine Translocon
Eva-Maria Strauch, Department of Chemistry and Biochemistry, University of Texas at Austin, 2500 Speedway, Austin, TX 78712 and George Georgiou, Chemical Engineering, University of Texas at Austin, 1 University Station C0400, Austin, TX 78712 |
Biomolecular Engineering for Improved Virus-like Particles
Natalie Connors1, Yap Pang Chuan1, Marcus Niebert1, Thomas Huber2 and Anton P. J. Middelberg1, (1)Centre for Biomolecular Engineering, Australian Institute of Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Australia, (2)School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, Australia |
Inducible Regulation of Osteoblastic Transdifferentiation and Mineralized Tissue Formation
Charles A. Gersbach1, Joseph M. Le Doux2, Robert E. Guldberg3 and Andres Garcia3, (1)Scripps Research Institute, La Jolla, CA 92037, (2)Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, (3)Mechanical Engineering, Georgia Institute of Technology, 311 Ferst Drive NW, Atlanta, GA 30309 |
Directed Evolution of a G-Protein Coupled Receptor
Casim A. Sarkar, Departments of Bioengineering and Chemical & Biomolecular Engineering, University of Pennsylvania, 240 Skirkanich Hall, 210 S. 33rd Street, Philadelphia, PA 19104-6321 and Andreas Plueckthun, Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, Zurich, CH-8057, Switzerland |
A Novel Method to Determine Serum Antibody Specificity Using Cell Surface Display
Sejal S. Hall and Patrick S. Daugherty, Chemical Engineering, University of California, Santa Barbara, Santa Barbara, CA 93101 |
Engineering AlphaL I Domain to Elucidate Molecular Structure-Function Relationship
Lauren R. Pepper, Department of Bioengineering, University of Pennsylvania, 220 S. 33rd St - 311A Towne, Philadelphia, PA 19104, Daniel A. Hammer, University of Pennsylvania, Philadelphia, PA 19104 and Eric T. Boder, Chemical and Biomolecular Engineering, University of Pennsylvania, 231 S. 34th Street, 176, Philadelphia, PA 19104 |
Engineering Epidermal Growth Factor for Wound Healing Applications
Stayce E. Beck1, Stephen S. Lee1, Daphne P. Ly2, Michael T. Longaker2, George P. Yang2 and Jennifer R. Cochran1, (1)Bioengineering, Stanford University Schools of Engineering and Medicine, 318 Campus Dr. West, MC5439, James H. Clark Center, W250, Stanford, CA 94305-5439, (2)Surgery, Stanford University School of Medicine, Children's Surgical Research Center, Stanford, CA 94305 |
A Liposome-Enhanced Microtiter Plate Assay for Cholera Toxin in Vibrio Cholerae-Infected Epithelial Cell Culture
Katie A. Edwards, Biological and Environmental Engineering, Cornell University, 145 Riley Robb Hall, Ithaca, NY 14853 and John C. March, Biological and Environmental Engineering, Cornell University, 220 Riley Robb Hall, Ithaca, NY 14853 |
Predicting Deactivation of Proteins in Salt Solutions for Accelerated Stability Evaluation of Biocatalysts and Therapeutic Proteins
James M. Broering and Andreas S. Bommarius, Chemical & Biomolecular Engineering, Georgia Tech, 315 Ferst Dr, Atlanta, GA 30332-0363 |
Specific Tumor Targeting Peptides Isolated from Fluorescent Bacterial Display Libraries
Karen Y. Dane, Claudia Gottstein and Patrick S. Daugherty, Chemical Engineering, UCSB, Engineering II, Room 3357, Santa Barbara, CA 93106-5080 |
Signal Transduction at Point-Blank Range: Computational Analysis of Spatially Coupled Ras/Phosphoinositide 3-Kinase Crosstalk
Michael Monine, Chemical & Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695-7905 and Jason Haugh, Chemical & Biomolecular Engineering, North Carolina State University, Box 7905, Engineering Bldg. I, 911 Partners Way, Raleigh, NC 27695-7905 |
Versatile Bacterial Surface Display
Jeffrey J. Rice, Chemical Engineering, UCSB, Engineering II, Room 3357, Santa Barbara, CA 93106-5080 and Patrick S. Daugherty, Chemical Engineering, University of California, Santa Barabara, Engineering II, Room 3357, Santa Barbara, CA 93106-5080 |
Designing Arac Effector Specificity through Modeling and Dual Selection
Patrick C. Cirino, Hossein Fazelinia, Shuang-Yan Tang and Costas Maranas, Penn State University, University Park, PA 16802 |
High-Throughput Protein Interaction Mapping Using FRET Hybrids
Xia You1, Annalee W. Nguyen2, Abeer Jabaiah1, Mark A. Sheff3, Kurt S. Thorn4 and Patrick S. Daugherty1, (1)Chemical Engineering, University of California, Santa Barbara, Santa Barbara, CA 93101, (2)Applied Biosystems, Austin, TX 78744, (3)Bauer Center for Genomics Research, Harvard University, Cambridge, 02138, (4)University of California, San Francisco, San Francisco,, CA 94158 |
Engineering and Characterization of Influenza Hemagglutinin
Jeong H. Lee, Department of Chemical and Biomolecular Engineering, University of Pennsylvania, 220 S. 33rd Street, Philadelphia, PA 19104, Mark Goulian, Department of Biology, University of Pennsylvania, 231 S. 34th Street, 176, Philadelphia, PA 19104 and Eric T. Boder, Department of Chemical and Biomolecular Engineering, University of Pennsylvania, 220 South 33rd Street, Philadelphia, PA 19104 |
Turning G Proteins on and off: Peptide Modulators of Signaling
Richard W. Roberts, Chemistry, Chemical Engineering, and Biology, University of Southern California, 3710 McClintock Ave, RTH 507, Los Angeles, CA 91030 |
Optimum Mmp-1 Substrates Identified Using Cellular Libraries of Peptide Substrates (Clips)
Kevin T. Boulware, Chemical Engineering, University of California, Santa Barbara, Engineering II, Rm 3357, Santa Barbara, CA 93106-5040 and Patrick S. Daugherty, Chemical Engineering, University of California, Santa Barabara, Engineering II, Room 3357, Santa Barbara, CA 93106-5080 |
On Modeling Metabolism
Jamey Young1, Jin Il Kim1, Doraiswami Ramkrishna1 and Jeffrey D. Varner2, (1)School of Chemical Engineering, Purdue University, West Lafayette, IN 47907-1283, (2)Department of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14850 |
A Test of the Bailey Complex Biology with No Parameters Hypothesis Using a Model of the Extrinsic Coagulation Cascade
D. Luan, M. Zai and Jeffrey D. Varner, Department of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14850 |
Identification of a Mechanistic Model of Calcium Crosstalk and Caspase Activation in Mammalian Apoptosis
Sang Ok Song, Anjali Dhiman and Jeffrey D. Varner, Department of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14850 |
The Predicted Points of Cell-Cycle Fragility Are Consistent with Known Malfunctions in Solid and Hematological Tumors
S. Nayak and Jeffrey D. Varner, Department of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14850 |
Improving Efficiency of Simultaneous Expression of Multiple Recombinant Proteins in an E. Coli Derived Cell Free Protein Synthesis System
Jungwon Keum1, Jin-Ho Ahn2, In-Suk Oh3, Tae-Wan Kim3, Cha-Yong Choi3 and Dong-Myung Kim4, (1)School of Chemical and Biological Engineering, Seoul National University, Seoul, South Korea, (2)Interdisciplinary Program for Biochemical Engineering and Biotechnology, Seoul National University, Seoul, South Korea, (3)Seoul National University, Seoul, South Korea, (4)Department of Fine Chemical Engineering and Chemistry, Chungnam National University, Seoul National University, Seoul, South Korea |
Efficient Protein Folding Procedure for Production of Eukaryotic Proteins in an E. Coli Cell-Free System
In-Seok Oh1, Tae-Wan Kim1, Jung-Won Keum2, Jin-Ho Ahn3, Cha-Yong Choi1 and Dong-Myung Kim1, (1)School of Chemical and Biological Engineering, Seoul National University, Seoul, South Korea, (2)School of Chemical Engineering, Seoul National University, Seoul, South Korea, (3)Interdisciplinary Program for Biochemical Engineering and Biotechnology, Seoul National University, Seoul, South Korea |
NMR Study of Diffusion in Lipid Membranes on the Nanoscale
Sergey Vasenkov1, Konstantin Ulrich2 and Monica Sanders1, (1)Chemical Engineering, University of Florida, Museum Road, Bldg. 723, Gainesville, FL 32611, (2)Physics, Universität Leipzig, Linnestrasse 5, Leipzig, 04103, Germany |
Aptamer-Microbead Conjugates Based Analysis System for Hepatitis C Virus
Bo-Rahm Lee1, Tae Seok Sim2, Sang-Myung Lee3, Kyoung-Soon Zang4, Min-Soo Kim2, Yoon-Sik Lee3, Yong-Kweon Kim2, June-Hyung Kim1 and Byung-Gee Kim3, (1)School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-742, South Korea, (2)School of Electrical Engineering and Computer Science, Seoul National University, Seoul, 151-742, South Korea, (3)School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-742, South Korea, (4)Interdisciplinary Program for Biochemical Engineering and Biotechnology, Seoul National University, Seoul, 151-742, South Korea |
Label-Free, Homogenous Detection of Viral Protein Using Rationally Designed Modular Allosteric Aptamer Sensor
June-Hyung Kim1, Gyeong Sook Bang2, Nahum Lee2, Suhyung Cho2, Bo-Rahm Lee2 and Byung-Gee Kim2, (1)School of Chemical and Biological Engineering, School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-742, South Korea, (2)School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-742, South Korea |
Fast Molecular Recognition Measurements Using Proteon Xpr 36 Protein Interaction Array
Sergei Bibikov1, T Bravman1 and G Schreiber2, (1)Bio-Rad Laboratories, Hercules, CA 94547, (2)Weizmann Institute, Bio-Rad Laboratories, Hercules, CA 94547 |
The Proteon(Tm) Xpr36 Protein Interaction Array System - a New Tool for Kinetic Studies of Biomolecular Interactions
Sergei Bibikov, Shai Nimri, Tsafrir Bravman, Rony Saguy, Kobi Lavie, Barak Liraz, Yochanan Uri, Boaz Ran and Ariel Notcovich, Bio-Rad Laboratories, Hercules, CA 94547 |
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