Preliminary Program subject to change
BEC101 Evolutionary Engineering of Proteins
OverviewThe ability to engineer proteins with desired properties is limited by our current understanding of the relationships between protein sequence, protein structure and protein function. Directed evolution is an effective design algorithm that can circumvent these limitations. This session will highlight emerging topics and recent successes in the directed evolution of proteins.
Primary SponsorEngineering Functional Biomolecules (BEC1)

Chair

Marc Ostermeier
Assistant Professor
Chemical and Biomolecular Engineering
Johns Hopkins University
3400 N. Charles St.
Baltimore, MD 21218
Phone Number: 410-516-7144
Email: oster@jhu.edu

CoChair

Andrew E. Nixon
Senior Director
Biochemistry Discovery Research
Dyax Corp.
300 Technology Square
Cambridge, MA 02139
Phone Number: (617) 250-5772
Email: anixon@dyax.com
Engineering Restriction-like Proteases for Proteomic and Therapeutic Applications
George Georgiou, Chemical Engineering, University of Texas at Austin, 1 University Station C0400, Austin, TX 78712
Generation, Mechanisms and Application of Chimeric Allosteric Hormone Sensors
David W. Wood, Alison Gillies and Georgios Skretas, Chemical Engineering, Princeton University, A213 EQUAD, Princeton, NJ 08544
Connecting Sequence Space and Chemical Space: Traversing Divergent Evolutionary Pathways in Terpene Cyclases
Paul E. O'Maille, The Jack H. Skirball Chemical Biology, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037, Nikki Dellas, The Department of Chemistry, University of California, San Diego, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037 and Joseph P. Noel, Professor, The Jack H. Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037
Insights into Molecular Recognition from Minimalist Synthetic Antibodies
Sachdev Sidhu, Dept of Protein Engineering, MS27, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080

General Submissions